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Article

Reengineering natural design by rational design and in vivo library selection: the HLH subdomain in bHLHZ proteins is a unique requirement for DNA-binding function.

Protein engineering, design & selection : PEDS - 1 May 2010

Xu Jing, De Jong Antonia T, Chen Gang, Chow Hiu-Kwan, Damaso Christopher O, Schwartz Mittelman Adrian, Shin Jumi A

Abstract excerpt

To explore the role of the HLH subdomain in bHLHZ proteins, we designed sets of minimalist proteins based on bHLHZ protein Max, bHLH/PAS protein Arnt and bZIP protein C/EBP. In the first, the Max bHLH and C/EBP leucine zipper were fused such that the leucine heptad repeats were not in register; t...

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Identifiers

PMID: 20086039
DOI: 10.1093/protein/gzp082
PMCID: PMC2851444

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20086039-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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