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Article

Aggressive chronic lymphocytic leukemia with elevated genomic complexity is associated with multiple gene defects in the response to DNA double-strand breaks.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2010

Ouillette Peter, Fossum Samuel, Parkin Brian, Ding Li, Bockenstedt Paula, Al-Zoubi Ammar, Shedden Kerby, Malek Sami N

Abstract excerpt

PURPOSE: Genomic complexity is present in approximately 15% to 30% of all chronic lymphocytic leukemia (CLL) and has emerged as a strong independent predictor of rapid disease progression and short remission duration in CLL. We conducted this study to advance our understanding of the causes of genomic complexity in CLL. EXPERIMENTAL DESIGN: We have obtained quantitative measurements of radiation-induced apoptosis...

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Identifiers

PMID: 20086003
DOI: 10.1158/1078-0432.CCR-09-2534
PMCID: PMC2818663

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