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The LIM and SH3 domain protein family: structural proteins or signal transducers or both?

1 Jan 2008

Abstract excerpt

LIM and SH3 Protein 1 (LASP-1) was initially identified from a cDNA library of metastatic axillary lymph nodes (MLN) more than a decade ago. It was found to be overexpressed in human breast and ovarian cancer and became the first member of a newly defined LIM-protein subfamily of the nebulin group characterized by the combined presence of LIM and SH3 domains. LASP2, a novel LASP1-related gene was first identified...

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PMID: 18419822
DOI: 10.1186/1476-4598-7-31

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