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Article

Microenvironmental modulation of asymmetric cell division in human lung cancer cells

13 Jan 2010

Abstract excerpt

Normal tissue homeostasis is maintained through asymmetric cell divisions that produce daughter cells with differing self-renewal and differentiation potentials. Certain tumor cell subfractions can self-renew and repopulate the heterogeneous tumor bulk, suggestive of asymmetric cell division, but an equally plausible explanation is that daughter cells of a symmetric division subsequently adopt differing cell...

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PMID: 20080668
DOI: 10.1073/pnas.0909390107

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