Article
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
The Journal of biological chemistry - 3 May 2013
Kabuta Tomohiro, Mitsui Takeshi, Takahashi Masaki, Fujiwara Yuuki, Kabuta Chihana, Konya Chiho, Tsuchiya Yukihiro, Hatanaka Yusuke, Uchida Kenko, Hohjoh Hirohiko, Wada Keiji
Abstract excerpt
Dysregulation of cell proliferation and the cell cycle are associated with various diseases, such as cancer. Cyclin-dependent kinases (CDKs) play central roles in cell proliferation and the cell cycle. Ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed in a restricted range of tissues, including the brain and numerous types of cancer. However, the molecular functions of UCH-L1 remain elusive. In this study,...
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