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Article

Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.

Science signaling - 20 Oct 2020

Liess Anna K L, Kucerova Alena, Schweimer Kristian, Schlesinger Dörte, Dybkov Olexandr, Urlaub Henning, Mansfeld Jörg, Lorenz Sonja

Abstract excerpt

At the heart of protein ubiquitination cascades, ubiquitin-conjugating enzymes (E2s) form reactive ubiquitin-thioester intermediates to enable efficient transfer of ubiquitin to cellular substrates. The precise regulation of E2s is thus crucial for cellular homeostasis, and their deregulation is frequently associated with tumorigenesis. In addition to driving substrate ubiquitination together with ubiquitin...

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Identifiers

PMID: 33082289
DOI: 10.1126/scisignal.aba8208
PMCID: PMC7613103

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