The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

Abstract excerpt

The ubiquitin-proteasome pathway plays a crucial role in many cellular processes by degrading substrates tagged by polyubiquitin chains, linked mostly through lysine 48 of ubiquitin. Although polymerization of ubiquitin via its six other lysine residues exists in vivo as part of various physiological pathways, the molecular mechanisms that determine the type of polyubiquitin chains remained largely unknown. We...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Arginine
• Share to Endopeptidases
• Share to Lysine