Article
Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1.
Leukemia research - 1 Mar 2002
Haase Detlef, Binder Claudia, Bünger Jürgen, Fonatsch Christa, Streubel Berthold, Schnittger Susanne, Griesinger Frank, Westphal Götz, Schoch Claudia, Knopp Agnes, Berkovicz Dinko, Krieger Otto, Wörmann Bernhard, Hilgers Reinhard, Hallier Ernst, Schulz Thomas
Abstract excerpt
The most serious long-term complications of anti-tumor therapy are secondary malignancies. Parameters which might allow an estimation of the individual risk to develop a therapy-induced neoplasia are urgently needed. We examined whether the genotypes of the glutathione S-transferases (GST) M1 and T1, which metabolize various cytostatic drugs, as well as reactive oxygen species, influence the risk for secondary...
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