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Article

Is the epidermal growth factor receptor status in lung cancers reflected in clinicopathologic features?

Archives of pathology & laboratory medicine - 1 Jan 2010

Inamura Kentaro, Ninomiya Hironori, Ishikawa Yuichi, Matsubara Osamu

Abstract excerpt

CONTEXT: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are molecular-targeted drugs that are innovatively effective for non-small cell lung carcinomas with EGFR mutations. Epidermal growth factor receptor is a transmembrane receptor forming dimers on ligand binding. These then stimulate signals by activating receptor autophosphorylation through tyrosine kinase activity. Autophosphorylation...

Topics

Adenocarcinoma
Adenocarcinoma, Bronchiolo-Alveolar
Enzyme Inhibitors
ErbB Receptors
Humans
Lung Neoplasms
Mutation
Protein-Tyrosine Kinases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20073607
DOI: 10.5858/2008-0586-RAR1.1

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20073607-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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