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Article

Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation.

The American journal of surgical pathology - 1 Oct 2006

Blons Hélène, Côté Jean-François, Le Corre Delphine, Riquet Marc, Fabre-Guilevin Elisabeth, Laurent-Puig Pierre, Danel Claire

Abstract excerpt

In lung cancer, an association was made between drastic clinical response to epidermal growth factor receptor (EGFR) inhibitors and the presence of somatic mutations within the tyrosine kinase domain of the EGFR. In some cases, patients with partial response or disease stabilization do not always have EGFR-mutated tumors. To go further in the characterization of the EGF pathway, we screened EGFR, ERBB2, ERBB3,...

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Topics

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Share to Adenocarcinoma, Bronchiolo-Alveolar
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to DNA, Neoplasm

Share to ErbB Receptors

Share to Lung Neoplasms

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Source

Identifiers

PMID: 17001163
DOI: 10.1097/01.pas.0000213285.65907.31

Genes

EGFR
EGF
KRAS
BRAF
ERBB2
ERBB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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