Article
Correlation between morphology and EGFR mutations in lung adenocarcinomas Significance of the micropapillary pattern and the hobnail cell type.
Lung cancer (Amsterdam, Netherlands) - 1 Feb 2009
Ninomiya Hironori, Hiramatsu Miyako, Inamura Kentaro, Nomura Kimie, Okui Michiyo, Miyoshi Tatsu, Okumura Sakae, Satoh Yukitoshi, Nakagawa Ken, Nishio Makoto, Horai Takeshi, Miyata Satoshi, Tsuchiya Eiju, Fukayama Masashi, Ishikawa Yuichi
Abstract excerpt
The presence of epidermal growth factor receptor (EGFR) tyrosine kinase (TK) mutations significantly correlates with tumor sensitivity to TK inhibitors, particularly in lung adenocarcinomas, the predominant histological subtype in Japan and the United States. To clarify links between EGFR mutations and pathological findings in Japanese lung cancer, detailed pathological features of adenocarcinomas were examined...
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