Article
A common mitochondrial polymorphism 10398A>G is associated metabolic syndrome in a Chinese population.
Mitochondrion - 1 Apr 2010
Juo Suh-Hang H, Lu Ming-Ying, Bai Ren-Kui, Liao Yi-Chu, Trieu Robert B, Yu Ming-Lung, Wong Lee-Jun C
Abstract excerpt
We conducted a two-step case-control study to investigate the association between mtDNA variants and metabolic syndrome (MS) in Chinese. We initially screened 79 mitochondrial single nucleotide polymorphisms (mtSNPs) in 141 cases and 506 controls, and five mtSNPs had a p<0.05. We replicated results for the most significant mtSNP 10398A>G in additional 396 case and 424 controls (p=0.047, OR=1.26). The G allele...
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