Article
The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status.
Diabetes research and clinical practice - 1 Sept 2011
Pérez María Silvia, Tellechea Mariana L, Aranguren Florencia, Taverna Mariano J, Rodríguez Ricardo G, Meroño Tomás, Brites Fernando, Poskus Edgardo, Frechtel Gustavo D
Abstract excerpt
AIMS: To explore associations between IRS-1 rs1801278 G>A polymorphism and metabolic syndrome (MS). METHODS: rs1801278 G>A was genotyped in 610 healthy Argentinian men. RESULTS: GA carriers had lower risk of MS (OR=0.52, P=0.045), particularly among smokers (OR=0.10, P=0.006). CONCLUSIONS: rs1801278 GA carriers had lower risk of MS, especially among smokers.
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