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Vaccinia virus decreases major histocompatibility complex (MHC) class II antigen presentation, T‐cell priming, and peptide association with MHC class II

15 May 2009

Abstract excerpt

Vaccinia virus (VACV) is the current live virus vaccine used to protect humans against smallpox and monkeypox, but its use is contraindicated in several populations because of its virulence. It is therefore important to elucidate the immune evasion mechanisms of VACV. We found that VACV infection of antigen-presenting cells (APCs) significantly decreased major histocompatibility complex (MHC) II antigen...

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PMID: 20067538
DOI: 10.1111/j.1365-2567.2009.03120.x

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