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Article

Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines

28 Dec 2004

Abstract excerpt

The large size of poxvirus genomes has stymied attempts to identify determinants recognized by CD8+ T cells and greatly impeded development of mouse smallpox vaccination models. Here, we use a vaccinia virus (VACV) expression library containing each of the predicted 258 open reading frames to identify five peptide determinants that account for approximately half of the VACV-specific CD8+ T cell response in...

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PMID: 15623576
DOI: 10.1084/jem.20041912

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