Article
Avipox-based simian immunodeficiency virus (SIV) vaccines elicit a high frequency of SIV-specific CD4+ and CD8+ T-cell responses in vaccinia-experienced SIVmac251-infected macaques.
Vaccine - 26 Jan 2004
Nacsa Janos, Radaelli Antonia, Edghill-Smith Yvette, Venzon David, Tsai Wen-Po, Morghen Carlo De Giuli, Panicali Dennis, Tartaglia Jim, Franchini Genoveffa
Abstract excerpt
The ability of ALVAC- or fowlpox-based simian immunodeficiency virus (SIV) vaccines to boost SIV-specific CD4+ and CD8+ T-cell responses was tested in 10 vaccinia-experienced macaques infected with SIVmac251. The CD8+ T-cell response to the dominant Gag(181-189) CM9 was quantitated in seven Mamu-A*01-positive macaques by tetramer staining, by ex vivo cytotoxic T-lymphocyte (CTL) activity, and by intracellular...
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