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Article

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

Neurobiology of disease - 1 Mar 2009

Colombo Alessio, Bastone Antonio, Ploia Cristina, Sclip Alessandra, Salmona Mario, Forloni Gianluigi, Borsello Tiziana

Abstract excerpt

Secretion of Amyloid-beta peptide (Abeta) circulating oligomers and their aggregate forms derived by processing of beta-amyloid precursor protein (APP) are a key event in Alzheimer's disease (AD). We show that phosphorylation of APP on threonine 668 may play a role in APP metabolism in H4-APP(sw) cell line, a degenerative AD model. We proved that JNK plays a fundamental role in this phosphorylation since its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19166938
DOI: 10.1016/j.nbd.2008.12.014

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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