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Article

The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity.

Oncogene - 25 Mar 2010

Baert J-L, Monte D, Verreman K, Degerny C, Coutte L, de Launoit Y

Abstract excerpt

In this study, we report that the PEA3 group members interact with the mammalian really interesting new gene (RING) E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1), which mediates ubiquitylation and subsequent proteasome degradation of the p53 and c-Jun transcription factors. This in...

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Source

Identifiers

PMID: 20062082
DOI: 10.1038/onc.2009.471

Genes

COP1
DET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20062082-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity.PMID 20062082Read ↗

14-3-3σ Exerts Tumor-Suppressor Activity Mediated by Regulation of COP1 StabilitySemantic proximity Read ↗

COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1.Semantic proximity Read ↗

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members.Semantic proximity Read ↗

Mammalian COP9 signalosomeSemantic proximity Read ↗

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in miceSemantic proximity Read ↗

Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation.Semantic proximity Read ↗

Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1.Semantic proximity Read ↗

The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex.Semantic proximity Read ↗

Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin Ligase Activity through Their Coiled-Coil Domains Association.Semantic proximity Read ↗

The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis.Semantic proximity Read ↗

Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis.Semantic proximity Read ↗

Characterization and Purification of the Mammalian COP9 Complex, a Conserved Nuclear Regulator Initially Identified as a Repressor of Photomorphogenesis in Higher PlantsSemantic proximity Read ↗

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