Article
Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin Ligase Activity through Their Coiled-Coil Domains Association.
PLoS genetics - 1 Dec 2015
Xu Dongqing, Lin Fang, Jiang Yan, Ling Junjie, Hettiarachchi Chamari, Tellgren-Roth Christian, Holm Magnus, Wei Ning, Deng Xing Wang
Abstract excerpt
CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) functions as an E3 ubiquitin ligase and mediates a variety of developmental processes in Arabidopsis by targeting a number of key regulators for ubiquitination and degradation. Here, we identify a novel COP1 interacting protein, COP1 SUPPRESSOR 2 (CSU2). Loss of function mutations in CSU2 suppress the constitutive photomorphogenic phenotype of cop1-6 in darkness. CSU2...
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