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Article

Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1.

Current biology : CB - 1 Jul 1999

Wang H, Kang D, Deng X W, Wei N

Abstract excerpt

Identified in Arabidopsis as a repressor of light-regulated development, the COP1 (constitutively photomorphogenic 1) protein is characterized by a RING-finger motif and a WD40 repeat domain [1]. The subcellular localization of COP1 is light-dependent. COP1 acts within the nucleus to repress photomorphogenic development, but light inactivates COP1 and diminishes its nuclear abundance [2]. Here, we report the...

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Identifiers

PMID: 10395541
DOI: 10.1016/s0960-9822(99)80314-5

Genes

COP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1.PMID 10395541Read ↗

The Photomorphogenic Central Repressor COP1: Conservation and Functional Diversification during Evolution.Semantic proximity Read ↗

COP1b, an isoform of COP1 generated by alternative splicing, has a negative effect on COP1 function in regulating light-dependent seedling development in Arabidopsis.Semantic proximity Read ↗

Genomic evidence for COP1 as a repressor of light-regulated gene expression and development in Arabidopsis.Semantic proximity Read ↗

Short communication: the N-terminal fragment of Arabidopsis photomorphogenic repressor COP1 maintains partial function and acts in a concentration-dependent manner.Semantic proximity Read ↗

Genetic and molecular analysis of an allelic series of cop1 mutants suggests functional roles for the multiple protein domains.Semantic proximity Read ↗

Characterization and Purification of the Mammalian COP9 Complex, a Conserved Nuclear Regulator Initially Identified as a Repressor of Photomorphogenesis in Higher PlantsSemantic proximity Read ↗

Isolation and molecular characterization of the COP1 gene homolog from rice, Oryza sativa L. subsp. Indica var. Pusa Basmati 1.Semantic proximity Read ↗

Overexpression of Arabidopsis COP1 results in partial suppression of light-mediated development: evidence for a light-inactivable repressor of photomorphogenesis.Semantic proximity Read ↗

Promotion of photomorphogenesis by COP1.Semantic proximity Read ↗

Cip4, a new COP1 target, is a nucleus-localized positive regulator of Arabidopsis photomorphogenesis.Semantic proximity Read ↗

Modular domain structure of Arabidopsis COP1. Reconstitution of activity by fragment complementation and mutational analysis of a nuclear localization signal in planta.Semantic proximity Read ↗

Expression of an N-terminal fragment of COP1 confers a dominant-negative effect on light-regulated seedling development in Arabidopsis.Semantic proximity Read ↗

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