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Article

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

14 Mar 2011

Abstract excerpt

Biochemical studies have suggested conflicting roles for the E3 ubiquitin ligase constitutive photomorphogenesis protein 1 (Cop1; also known as Rfwd2) in tumorigenesis, providing evidence for both the oncoprotein c-Jun and the tumor suppressor p53 as its targets. Here we present what we believe to be the first in vivo investigation of the role of Cop1 in cancer etiology. Using an innovative genetic approach to...

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PMID: 21403399
DOI: 10.1172/jci45784

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Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in micePMID 21403399Read ↗

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Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time.Semantic proximity Read ↗

The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity.Semantic proximity Read ↗

Overexpression of Arabidopsis COP1 results in partial suppression of light-mediated development: evidence for a light-inactivable repressor of photomorphogenesis.Semantic proximity Read ↗

CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis.Semantic proximity Read ↗

COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation.Semantic proximity Read ↗

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