Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.

1 Jul 2003

Abstract excerpt

Interleukin-7 (IL-7) plays an important role in the normal development and maintenance of the human immune system. Its effects are mediated via its receptor, IL-7R. Ligand-receptor engagement results in a cascade of phosphorylation events mediated by various molecules including the Janus kinases (Jak1 and Jak3), PI3-kinase, Stats (signal transducers and activators of transcription) and other molecules. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to HER2/EGFR in Cancer Research
Share to Medicinal Plant Pharmacodynamics Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12792903
DOI: 10.14670/hh-18.911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.PMID 12792903Read ↗

Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia.Semantic proximity Read ↗

The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy.Semantic proximity Read ↗

The pleiotropic effects of interleukin 7 and their pathologic and therapeutic implications.Semantic proximity Read ↗

The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells.Semantic proximity Read ↗

Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer.Semantic proximity Read ↗

IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers.Semantic proximity Read ↗

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic AgentSemantic proximity Read ↗

Interleukin-7: Fuel for the autoimmune attack.Semantic proximity Read ↗

IL7-receptor expression is frequent in T-cell acute lymphoblastic leukemia and predicts sensitivity to JAK-inhibitionSemantic proximity Read ↗

Deleterious and Oncogenic Mutations in the IL7RASemantic proximity Read ↗

The B7 Homologues and their Receptors in Hematologic MalignanciesSemantic proximity Read ↗

Signal transducer and activator of transcription (STAT) signalling and T‐cell lymphomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.