Article
Translation is enhanced after silent nucleotide substitutions in A+T- rich sequences of the coding region of CD46 cDNA.
European journal of biochemistry - 15 May 1996
Milland J, Christiansen D, Thorley B R, McKenzie I F, Loveland B E
Abstract excerpt
Specific sequences in the coding region of CD46 (membrane cofactor protein) transcripts have been shown to have a marked effect on translation. Two A+T-rich regions of CD46 cDNA were altered by mutation without changing the CD46 amino acid sequence (silent nucleotide substitution). In one region,...
Topics
- Adenosine
- Animals
- Antigens, CD
- Base Sequence
- Cells, Cultured
- DNA, Complementary
- Enhancer Elements, Genetic
- Membrane Cofactor Protein
- Membrane Glycoproteins
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Plasmids
- Protein Biosynthesis
- Recombinant Proteins
- Thymidine
- Transfection