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Article

Differential Insulin Secretion of High-Fat Diet-Fed C57BL/6NN and C57BL/6NJ Mice: Implications of Mixed Genetic Background in Metabolic Studies.

PloS one - 1 Jan 2016

Attané Camille, Peyot Marie-Line, Lussier Roxane, Zhang Dongwei, Joly Erik, Madiraju S R Murthy, Prentki Marc

Abstract excerpt

Many metabolic studies employ tissue-specific gene knockout mice, which requires breeding of floxed gene mice, available mostly on C57BL/6N (NN) genetic background, with cre or Flp recombinase-expressing mice, available on C57BL/6J (JJ) background, resulting in the generation of mixed C57BL/6NJ (NJ) genetic background mice. Recent awareness of many genetic differences between NN and JJ strains including the...

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Identifiers

PMID: 27403868
DOI: 10.1371/journal.pone.0159165
PMCID: PMC4942110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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