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Article

Taming active transposons at Drosophila telomeres: The interconnection between HipHop's roles in capping and transcriptional silencing.

PLoS genetics - 1 Nov 2021

Cui Min, Bai Yaofu, Li Kaili, Rong Yikang S

Abstract excerpt

Drosophila chromosomes are elongated by retrotransposon attachment, a process poorly understood. Here we characterized a mutation affecting the HipHop telomere-capping protein. In mutant ovaries and the embryos that they produce, telomere retrotransposons are activated and transposon RNP accumulates. Genetic results are consistent with that this hiphop mutation weakens the efficacy of HP1-mediated silencing while...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34813587
DOI: 10.1371/journal.pgen.1009925
PMCID: PMC8651111

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