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Article

Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility.

BMC medicine - 17 May 2012

Ji Guixiang, Long Yan, Zhou Yong, Huang Cong, Gu Aihua, Wang Xinru

Abstract excerpt

BACKGROUND: The mismatch repair (MMR) pathway plays an important role in the maintenance of the genome integrity, meiotic recombination and gametogenesis. This study investigated whether genetic variations in MMR genes are associated with an increased risk of sperm DNA damage and male infertility. METHODS: We selected and genotyped 21 tagging single nucleotide polymorphisms (SNPs) in five MMR genes (MLH1, MLH3,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22594646
DOI: 10.1186/1741-7015-10-49
PMCID: PMC3378460

Genes

PMS2
MLH1
MSH5
MLH3
MSH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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