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Article

Biological effects of T315I-mutated BCR-ABL in an embryonic stem cell-derived hematopoiesis model.

Experimental hematology - 1 Apr 2013

Melkus Michael, Bennaceur-Griscelli Annelise, Valogne Yannick, Flamant Stephane, Chomel Jean-Claude, Sorel Nathalie, Bonnet Marie-Laure, Deininger Michael W, Mitjavila-Garcia Maria-Teresa, Turhan Ali G

Abstract excerpt

The occurrence of T315I mutation during the course of targeted therapies of chronic myeloid leukemia is a major concern because it confers resistance to all currently approved tyrosine kinase inhibitors. The exact phenotype of the hematopoietic stem cell and the hierarchical level of the occurrence of this mutation in leukemic hematopoiesis has not been determined. To study the effects of T315I-mutated breakpoint...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23287417
DOI: 10.1016/j.exphem.2012.12.004

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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