Article
The C. elegans F-box/WD-repeat protein LIN-23 functions to limit cell division during development.
Development (Cambridge, England) - 1 Dec 2000
Kipreos E T, Gohel S P, Hedgecock E M
Abstract excerpt
In multicellular eukaryotes, a complex program of developmental signals regulates cell growth and division by controlling the synthesis, activation and degradation of G(1) cell cycle regulators. Here we describe the lin-23 gene of Caenorhabditis elegans, which is required to restrain cell proliferation in response to developmental cues. In lin-23 null mutants, all postembryonic blast cells undergo extra...
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