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Article

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype.

British journal of cancer - 2 Feb 2010

Ameri K, Luong R, Zhang H, Powell A A, Montgomery K D, Espinosa I, Bouley D M, Harris A L, Jeffrey S S

Abstract excerpt

BACKGROUND: Tumours contain hypoxic regions that select for an aggressive cell phenotype; tumour hypoxia induces metastasis-associated genes. Treatment refractory patients with metastatic cancer show increased numbers of circulating tumour cells (CTCs), which are also associated with disease prog...

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Source

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Identifiers

PMID: 20051957
DOI: 10.1038/sj.bjc.6605491
PMCID: PMC2805847

Genes

ATF3
ATF4
ASNS
BCL2
BNIP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20051957-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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