Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype.

British journal of cancer - 2 Feb 2010

Ameri K, Luong R, Zhang H, Powell A A, Montgomery K D, Espinosa I, Bouley D M, Harris A L, Jeffrey S S

Abstract excerpt

BACKGROUND: Tumours contain hypoxic regions that select for an aggressive cell phenotype; tumour hypoxia induces metastasis-associated genes. Treatment refractory patients with metastatic cancer show increased numbers of circulating tumour cells (CTCs), which are also associated with disease progression. The aim of this study was to examine the as yet unknown relationship between hypoxia and CTCs. METHODS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 4
Share to Cell Hypoxia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Lung Neoplasms

Share to Mice, Inbred NOD

Share to Neoplasm Transplantation

Share to Neoplastic Cells, Circulating

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 20051957
DOI: 10.1038/sj.bjc.6605491
PMCID: PMC2805847

Genes

ATF3
ATF4
ASNS
BCL2
BNIP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype.PMID 20051957Read ↗

Ex Vivo Expansion of Circulating Tumour Cells (CTCs)Semantic proximity Read ↗

Ex vivo expansion of circulating tumour cells (CTCs).Semantic proximity Read ↗

Intermittent hypoxia induces a metastatic phenotype in breast cancer.Semantic proximity Read ↗

Hypoxia and cancer.Semantic proximity Read ↗

Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies.Semantic proximity Read ↗

Biological consequences of tumor hypoxia.Semantic proximity Read ↗

Hypoxia-driven selection of the metastatic phenotype.Semantic proximity Read ↗

A gene for all seasons: The evolutionary consequences of HIF-1 in carcinogenesis, tumor growth and metastasisSemantic proximity Read ↗

Red blood cell-tumour cell interactions promote tumour cell progressionSemantic proximity Read ↗

Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance.Semantic proximity Read ↗

Enumeration, characterisation and clinicopathological significance of circulating tumour cells in patients with colorectal carcinoma.Semantic proximity Read ↗

Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.