Article
Biological consequences of tumor hypoxia.
Seminars in oncology - 1 Apr 2001
Höckel M, Vaupel P
Abstract excerpt
Growing evidence from experimental and clinical studies points to the fundamental, pathophysiologic role of hypoxia in solid tumors. Intratumoral hypoxia is a consequence of a structurally and functionally disturbed microcirculation, with deterioration of the diffusion geometry and of tumor-associated anemia. Hypoxia-induced changes of the proteome in the neoplastic and stroma cells may lead to neoplastic growth...
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