Article
Ex vivo expansion of circulating tumour cells (CTCs).
Scientific reports - 6 Mar 2023
Mohamed Bashir M, Ward Mark P, Bates Mark, Spillane Cathy D, Kelly Tanya, Martin Cara, Gallagher Michael, Heffernan Sheena, Norris Lucy, Kennedy John, Saadeh Feras Abu, Gleeson Noreen, Brooks Doug A, Brooks Robert D, Selemidis Stavros, O'Toole Sharon, O'Leary John J
Abstract excerpt
Circulating tumour cells (CTCs) are a critical intermediate step in the process of cancer metastasis. The reliability of CTC isolation/purification has limited both the potential to report on metastatic progression and the development of CTCs as targets for therapeutic intervention. Here we report a new methodology, which optimises the culture conditions for CTCs using primary cancer cells as a model system. We...
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