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Article

Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition.

The Journal of pharmacology and experimental therapeutics - 1 Apr 2010

Kelly Mairead, Trudel Stephanie, Brouillard Franck, Bouillaud Frederick, Colas Julien, Nguyen-Khoa Thao, Ollero Mario, Edelman Aleksander, Fritsch Janine

Abstract excerpt

Two highly potent and selective cystic fibrosis (CF) transmembrane regulator (CFTR) inhibitors have been identified by high-throughput screening: the thiazolidinone CFTR(inh)-172 [3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]- 2-thioxo-4-thiazolidinone] and the glycine hydrazide Gl...

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Source

Identifiers

PMID: 20051483
DOI: 10.1124/jpet.109.162032

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20051483-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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