Article
Phenylhydrazones as Correctors of a Mutant Cystic Fibrosis Transmembrane Conductance Regulator.
Archiv der Pharmazie - 1 Feb 2016
Nieddu Erika, Pollarolo Benedetta, Mazzei Marco T, Anzaldi Maria, Schenone Silvia, Pedemonte Nicoletta, Galietta Luis J V, Mazzei Mauro
Abstract excerpt
The phenylhydrazone RDR-1 is endowed with moderate activity as F508del-CFTR corrector; nevertheless, its simple structure enables stimulating developments in this class of correctors. Therefore, we synthesized a number of phenylhydrazones 3 by reacting phenylhydrazine derivatives 1 with furfural derivatives 2. By the same reaction, also the pyridine derivatives 4, the thiophene derivatives 5, and the hydrazides 6...
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