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Article

Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore.

Nature communications - 6 Aug 2024

Gao Xiaolong, Yeh Han-I, Yang Zhengrong, Fan Chen, Jiang Fan, Howard Rebecca J, Lindahl Erik, Kappes John C, Hwang Tzyh-Chang

Abstract excerpt

Loss-of-function mutations of the CFTR gene cause the life-shortening genetic disease cystic fibrosis (CF), whereas overactivity of CFTR may lead to secretory diarrhea and polycystic kidney disease. While effective drugs targeting the CFTR protein have been developed for the treatment of CF, little progress has been made for diseases caused by hyper-activated CFTR. Here, we solve the cryo-EM structure of CFTR in...

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Source

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Identifiers

PMID: 39107303
DOI: 10.1038/s41467-024-50641-1
PMCID: PMC11303713

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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