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Article

Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized.

Cancer cell - 16 Nov 2010

Quintana Elsa, Shackleton Mark, Foster Hannah R, Fullen Douglas R, Sabel Michael S, Johnson Timothy M, Morrison Sean J

Abstract excerpt

We investigated whether melanoma is hierarchically organized into phenotypically distinct subpopulations of tumorigenic and nontumorigenic cells or whether most melanoma cells retain tumorigenic capacity, irrespective of their phenotype. We found 28% of single melanoma cells obtained directly fro...

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Source

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Identifiers

PMID: 21075313
DOI: 10.1016/j.ccr.2010.10.012
PMCID: PMC3031091

Genes

ABCB5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21075313-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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