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Mapping of a locus correcting lack of phosphoribosylaminoimidazole carboxylase activity in Chinese hamster ovary cell Ade-D mutants to human chromosome 4.

Genomics - 1 Feb 1991

Barton J W, Hart I M, Patterson D

Abstract excerpt

The human phosphoribosylaminoimidazole (AIR) carboxylase locus has been until this report one of the genes encoding purine biosynthetic enzymes that had not been assigned to an individual human chromosome. Characterization of Chinese hamster ovary (CHO) cell mutant Ade-D showed that the cell line was unable to produce IMP and accumulated AIR. CHO Ade-D cells were fused with normal human lymphocytes utilizing...

Topics

Animals
Bromodeoxyuridine
Carboxy-Lyases
Cell Line
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 4
Cricetinae
Humans
Hybrid Cells
Mutation

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Identifiers

PMID: 2004782
DOI: 10.1016/0888-7543(91)90259-h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2004782-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mapping of a locus correcting lack of phosphoribosylaminoimidazole carboxylase activity in Chinese hamster ovary cell Ade-D mutants to human chromosome 4.PMID 2004782Read ↗

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