Article
Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders.
Molecular genetics and metabolism - 1 Mar 2013
Duval Nathan, Luhrs Kyleen, Wilkinson Terry G, Baresova Veronika, Skopova Vaclava, Kmoch Stanislav, Vacano Guido N, Zikanova Marie, Patterson David
Abstract excerpt
Purines are molecules essential for many cell processes, including RNA and DNA synthesis, regulation of enzyme activity, protein synthesis and function, energy metabolism and transfer, essential coenzyme function, and cell signaling. Purines are produced via the de novo purine biosynthesis pathway. Mutations in purine biosynthetic genes, for example phosphoribosylaminoimidazole...
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