Article
Role of the surface loop on the structure and biological activity of angiogenin.
BMB reports - 31 Dec 2009
Jang Seung Hwan, Song Hyang Do, Kang Dong Ku, Chang Soo Ik, Kim Min Kyung, Cho Kwang Hwi, Scheraga Harold A, Shin Hang Cheol
Abstract excerpt
Angiogenin is a member of the ribonuclease superfamily that induces the formation of new blood vessels. It has been suggested that the surface loop of angiogenin defined by residues 59-71 plays a special role in angiogenic function (1); however, the mechanism of action is not clearly defined. To elucidate the role of the surface loop on the structure, function and stability of angiogenin, three surface loop...
Topics
- Enzyme Stability
- Mutation
- Protein Conformation
- Ribonuclease, Pancreatic
- Structure-Activity Relationship
- Surface Properties