Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replacement of residues 8-22 of angiogenin with 7-21 of RNase A selectively affects protein synthesis inhibition and angiogenesis.

Biochemistry - 3 Apr 1990

Bond M D, Vallee B L

Abstract excerpt

The region of human angiogenin containing residues 8-21 is highly conserved in angiogenins from four mammalian species but differs substantially from the corresponding region of the homologous protein ribonuclease A (RNase A). Regional mutagenesis has been employed to replace this segment of angiogenin with the corresponding RNase A sequence, and the activities of the resulting covalent angiogenin/RNase hybrid,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Kinetics

Share to Molecular Sequence Data

Share to Mutation

Share to Protein Conformation

Source

Identifiers

PMID: 1692238
DOI: 10.1021/bi00465a028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replacement of residues 8-22 of angiogenin with 7-21 of RNase A selectively affects protein synthesis inhibition and angiogenesis.PMID 1692238Read ↗

Three decades of research on angiogenin: a review and perspectiveSemantic proximity Read ↗

Modular mutagenesis of human placental ribonuclease inhibitor, a protein with leucine-rich repeats.Semantic proximity Read ↗

The angiogenins: An emerging family of ribonuclease related proteins with diverse cellular functionsSemantic proximity Read ↗

Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A.Semantic proximity Read ↗

Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.Semantic proximity Read ↗

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.Semantic proximity Read ↗

Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal "hot spot".Semantic proximity Read ↗

Engineered human angiogenin mutations in the placental ribonuclease inhibitor complex for anticancer therapy: Insights from enhanced sampling simulations.Semantic proximity Read ↗

Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth.Semantic proximity Read ↗

Genetic selection for critical residues in ribonucleases.Semantic proximity Read ↗

Hypersensitive substrate for ribonucleasesSemantic proximity Read ↗

Role of the surface loop on the structure and biological activity of angiogenin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.