Article
Replacement of residues 8-22 of angiogenin with 7-21 of RNase A selectively affects protein synthesis inhibition and angiogenesis.
Biochemistry - 3 Apr 1990
Bond M D, Vallee B L
Abstract excerpt
The region of human angiogenin containing residues 8-21 is highly conserved in angiogenins from four mammalian species but differs substantially from the corresponding region of the homologous protein ribonuclease A (RNase A). Regional mutagenesis has been employed to replace this segment of angi...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Cloning, Molecular
- Gene Expression
- Humans
- In Vitro Techniques
- Kinetics
- Molecular Sequence Data
- Mutation
- Neovascularization, Pathologic
- Protein Biosynthesis
- Protein Conformation
- Protein Engineering
- Proteins
- Ribonuclease, Pancreatic