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Article

Modular mutagenesis of human placental ribonuclease inhibitor, a protein with leucine-rich repeats.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990

Lee F S, Vallee B L

Abstract excerpt

Human placental ribonuclease inhibitor (PRI) is a potent protein inhibitor of pancreatic ribonucleases and the homologous blood vessel-inducing protein angiogenin. Although inhibition by PRI occurs with a 1:1 stoichiometry, its primary structure is composed predominantly of seven internal leucine...

Topics

Amino Acid Sequence
Cloning, Molecular
Escherichia coli
Female
Humans
Kinetics
Leucine
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Placental Hormones
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pregnancy

Repetitive Sequences, Nucleic Acid

Ribonuclease, Pancreatic

Ribonucleases

Source

Open in PubMed Open full text

Identifiers

PMID: 2408043
DOI: 10.1073/pnas.87.5.1879
PMCID: PMC53587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2408043-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Modular mutagenesis of human placental ribonuclease inhibitor, a protein with leucine-rich repeats.PMID 2408043Read ↗

Kinetic characterization of two active mutants of placental ribonuclease inhibitor that lack internal repeats.Semantic proximity Read ↗

Replacement of residues 8-22 of angiogenin with 7-21 of RNase A selectively affects protein synthesis inhibition and angiogenesis.Semantic proximity Read ↗

Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal "hot spot".Semantic proximity Read ↗

Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A.Semantic proximity Read ↗

The angiogenins: An emerging family of ribonuclease related proteins with diverse cellular functionsSemantic proximity Read ↗

Genetic selection for critical residues in ribonucleases.Semantic proximity Read ↗

[Anti-oxidative effect of ribonuclease inhibitor by site-directed mutagenesis and expression in Pichia pastoris].Semantic proximity Read ↗

Role of the surface loop on the structure and biological activity of angiogenin.Semantic proximity Read ↗

Interaction of human placental ribonuclease with placental ribonuclease inhibitorSemantic proximity Read ↗

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