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Article

Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level.

Genome biology - 1 Jan 2010

Harismendy Olivier, Bansal Vikas, Bhatia Gaurav, Nakano Masakazu, Scott Michael, Wang Xiaoyun, Dib Colette, Turlotte Edouard, Sipe Jack C, Murray Sarah S, Deleuze Jean Francois, Bafna Vineet, Topol Eric J, Frazer Kelly A

Abstract excerpt

BACKGROUND: Targeted re-sequencing of candidate genes in individuals at the extremes of a quantitative phenotype distribution is a method of choice to gain information on the contribution of rare variants to disease susceptibility. The endocannabinoid system mediates signaling in the brain and peripheral tissues involved in the regulation of energy balance, is highly active in obese patients, and represents a...

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Identifiers

PMID: 21118518
DOI: 10.1186/gb-2010-11-11-r118
PMCID: PMC3156957

Genes

FAAH
MGLL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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