Article
Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium.
Stroke - 1 Feb 2010
Debette Stéphanie, Bis Joshua C, Fornage Myriam, Schmidt Helena, Ikram M Arfan, Sigurdsson Sigurdur, Heiss Gerardo, Struchalin Maksim, Smith Albert V, van der Lugt Aad, DeCarli Charles, Lumley Thomas, Knopman David S, Enzinger Christian, Eiriksdottir Gudny, Koudstaal Peter J, DeStefano Anita L, Psaty Bruce M, Dufouil Carole, Catellier Diane J, Fazekas Franz, Aspelund Thor, Aulchenko Yurii S, Beiser Alexa, Rotter Jerome I, Tzourio Christophe, Shibata Dean K, Tscherner Maria, Harris Tamara B, Rivadeneira Fernando, Atwood Larry D, Rice Kenneth, Gottesman Rebecca F, van Buchem Mark A, Uitterlinden Andre G, Kelly-Hayes Margaret, Cushman Mary, Zhu Yicheng, Boerwinkle Eric, Gudnason Vilmundur, Hofman Albert, Romero Jose R, Lopez Oscar, van Duijn Cornelia M, Au Rhoda, Heckbert Susan R, Wolf Philip A, Mosley Thomas H, Seshadri Sudha, Breteler Monique M B, Schmidt Reinhold, Launer Lenore J, Longstreth W T
Abstract excerpt
BACKGROUND AND PURPOSE: Previous studies examining genetic associations with MRI-defined brain infarct have yielded inconsistent findings. We investigated genetic variation underlying covert MRI infarct in persons without histories of transient ischemic attack or stroke. We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging...
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