Article
ERG-APLNR axis controls pulmonary venule endothelial proliferation in pulmonary veno-occlusive disease.
Circulation - 30 Sept 2014
Lathen Christopher, Zhang Yu, Chow Jennifer, Singh Martanday, Lin Grace, Nigam Vishal, Ashraf Yasser A, Yuan Jason X, Robbins Ivan M, Thistlethwaite Patricia A
Abstract excerpt
BACKGROUND: Pulmonary veno-occlusive disease is caused by excessive cell proliferation and fibrosis, which obliterate the lumen of pulmonary venules, leading to pulmonary hypertension, right ventricular failure, and death. This condition has no effective treatment and a 5-year survival of <5%. Understanding the mechanism of this disease and designing effective therapies are urgently needed. METHODS AND RESULTS:...
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