Article
Role of the EHD2 unstructured loop in dimerization, protein binding and subcellular localization.
PloS one - 1 Jan 2015
Bahl Kriti, Naslavsky Naava, Caplan Steve
Abstract excerpt
The C-terminal Eps 15 Homology Domain proteins (EHD1-4) play important roles in regulating endocytic trafficking. EHD2 is the only family member whose crystal structure has been solved, and it contains an unstructured loop consisting of two proline-phenylalanine (PF) motifs: KPFRKLNPF. In contrast, despite EHD2 having nearly 70% amino acid identity with its paralogs, EHD1, EHD3 and EHD4, the latter proteins...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Motifs
- Amino Acid Sequence
- Carrier Proteins
- Cell Membrane
- Green Fluorescent Proteins
- HeLa Cells
- Humans
- Microscopy, Confocal
- Models, Molecular
- Mutation