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Successful cross‐breeding of cloned pigs expressing endo‐β‐galactosidase C and human decay accelerating factor

1 Nov 2009

Abstract excerpt

BACKGROUND: For successful organ xenotransplantation, genetically engineered pigs have been actively produced. Our attention has focused on (i) reduction of alphaGal expression by its digestion enzyme, endo-beta-galactosidase C (EndoGalC), and (ii) inhibition of complement activation by human decay accelerating factor (hDAF). Cell sorting and nuclear transfer enabled the effective production of cloned pigs...

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PMID: 20042051
DOI: 10.1111/j.1399-3089.2009.00549.x

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