Genotoxic effects of high-energy iron particles in human lymphoblasts differing in radiation sensitivity.

doi:10.1667/0033-7587(2001)156[0186:geohei]2.0.co;2

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Article

Genotoxic effects of high-energy iron particles in human lymphoblasts differing in radiation sensitivity.

Radiation research - 1 Aug 2001

Evans H H, Horng M F, Evans T E, Jordan R, Schwartz J L

Abstract excerpt

The effects of (56)Fe particles and (137)Cs gamma radiation were compared in TK6 and WTK1 human lymphoblasts, two related cell lines which differ in TP53 status and in the ability to rejoin DNA double-strand breaks. Both cell lines were more sensitive to the cytotoxic and clastogenic effects of (56)Fe particles than to those of gamma rays. However, the mutagenicity of (56)Fe particles and gamma rays at the TK...

Topics

Cell Line
Cell Survival
Cesium Radioisotopes
Chromosome Aberrations
DNA Damage
DNA Repair
Gamma Rays
Genes, p53
Humans
Iron
Linear Energy Transfer
Lymphocytes
Mutagens
Mutation
Radiation Tolerance

Source

Open in PubMed

Identifiers

PMID: 11448240
DOI: 10.1667/0033-7587(2001)156[0186:geohei]2.0.co;2

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