Article
A direct phenotypic comparison of siRNA pools and multiple individual duplexes in a functional assay.
PloS one - 29 Dec 2009
Parsons Brendon D, Schindler Anja, Evans David H, Foley Edan
Abstract excerpt
BACKGROUND: RNAi is a prominent tool for the identification of novel regulatory elements within complex cellular pathways. In invertebrates, RNAi is a relatively straightforward process, where large double-stranded RNA molecules initiate sequence-specific transcript destruction in target cells. In contrast, RNAi in mammalian cell culture assays requires the delivery of short interfering RNA duplexes to target...
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