Article
Minimizing the risk of reporting false positives in large-scale RNAi screens.
Nature methods - 1 Oct 2006
Echeverri Christophe J, Beachy Philip A, Baum Buzz, Boutros Michael, Buchholz Frank, Chanda Sumit K, Downward Julian, Ellenberg Jan, Fraser Andrew G, Hacohen Nir, Hahn William C, Jackson Aimee L, Kiger Amy, Linsley Peter S, Lum Lawrence, Ma Yong, Mathey-Prévôt Bernard, Root David E, Sabatini David M, Taipale Jussi, Perrimon Norbert, Bernards René
Abstract excerpt
Large-scale RNA interference (RNAi)-based analyses, very much as other 'omic' approaches, have inherent rates of false positives and negatives. The variability in the standards of care applied to validate results from these studies, if left unchecked, could eventually begin to undermine the credi...
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