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Article

Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells

30 Apr 2010

Abstract excerpt

BACKGROUND: Translational control mediated by non-coding microRNAs (miRNAs) plays a key role in the mechanism of cellular resistance to anti-cancer drug treatment. Dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS, TS) are two of the most important targets for antifolate- and fluoropyrimidine-based chemotherapies in the past 50 years. In this study, we investigated the roles of miR-215 in the...

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PMID: 20433742
DOI: 10.1186/1476-4598-9-96

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