Article
Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation.
Nature communications - 20 Jan 2015
Wang Lizhong, Liu Runhua, Ye Peiying, Wong Chunshu, Chen Guo-Yun, Zhou Penghui, Sakabe Kaoru, Zheng Xincheng, Wu Wei, Zhang Peng, Jiang Taijiao, Bassetti Michael F, Jube Sandro, Sun Yi, Zhang Yanping, Zheng Pan, Liu Yang
Abstract excerpt
CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. CD24 competitively inhibits ARF binding to NPM, resulting in decreased ARF, increase MDM2 and...
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